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Electronic Coupling of Redox Enzymes to Electrodes for Applications in Sensing and Synthesis Membrane-bound redox enzymes constitute a neglected, but large and important, class of enzymes. The cell membrane provides the scaffolding upon which these enzymes arrange into systems for multi-step catalytic processes. The reconstruction of portions of this redox catalytic machinery, interfaced to an electrical power source, leads to novel synthesis and sensing devices. We currently are developing a variety biosensors and biocatalytic systems for chiral synthesis based on this approach. Project Overview
An amperometric fructose biosensor Biosensors incorporate a biological component for highly selective molecular recognition. An electrochemical version of enzyme-modified immunoassay technology (EMIT) has been demonstrated for potential detection of endocrine disruptors in the environment. Also, we are collaborating with UCLA neuroscientists in the design of in vivo biosensors for neurotransmitters to facilitate study of Parkinson’s disease. Students
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